With the increasing rollout of COVID-19 vaccines every day, people are increasingly asking which vaccine is best?
Even though this article tried to answer the question of which vaccine is “best”. It is not that simple because does that mean the vaccine is better at protecting you from serious disease? The one that protects you from any of the variants is circulating near you?
Until a lot of vaccines becomes accessible, many people around the world will be vaccinated with whatever vaccine is available in their area. This has been founded on available clinical data and on what your doctor advises if you have a medical condition.
Here’s why it’s so difficult to compare COVID vaccines.
- The common thinking is that clinical trials would provide explanations about which vaccine is “best”, particularly when the phase 3 trials are used as the basis of authorization by regulatory authorities around the world. However, these trials are usually carried out on tens of thousands of people and may fail to distinguish the number of COVID-19 cases in people who get the vaccine, versus those who get a placebo. These trials are to give a measure of efficacy, or how well the vaccine functions under the tightly controlled circumstances surrounding of a clinical trial.
This means the ratio of infection in the community, public health measures taken and the mix of distinct viral variants can vary.
- One way to compare vaccine efficacy directly is to run one-on-one studies. These studies would compare outcomes of people receiving one vaccine with those who receive another, in the same trial.
However, these trials are determined by efficacy, the study population, and other factors which are measured to know any differences in outcomes must be down to some disparities between the vaccines. Hence, a laborious endeavour
Presently, the two popular vaccines Pfizer-BioNTech vaccine and Moderna.
The Pfizer-BioNTech became the first COVID-19 vaccine to receive a Food and Drug Administration (FDA) in December 2020.
It is being used in the U.S. and other countries, including in the European Union for anyone above the age of twelve.
Unlike other vaccines (which put an inactivated disease germ into the body) the Pfizer mRNA vaccine provides a tiny piece of genetic code from the SARS CoV-2 virus to the host cells in the body, practically providing those cells instructions, or blueprints, for making copies of spike proteins.
Moderna vaccine on the other hand sends instructions to the cell in the body. This will create a spike protein which will train the body’s immune system to recognize it and then the immune system attacks the spike protein the next time it sees it. In order words, it is a little similar to the Prizer
Now to the answer to this question many ask, Which vaccine is the best?
The best vaccine is the one you can get now!
This is because it stops you from catching COVID-19, reduces transmission to vulnerable members of our community and substantially lessens your risk of severe disease.
From a collective perspective, all available vaccines do this job and do it well.
In conclusion, while it is important to be vaccinated against the virus, it is also important to ensure you take necessary cautionary steps to avoid getting infected.